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US4210590A Reduction of indole compounds to indoline

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WO2014102588A3 - Indole and indoline-type piperidine .

The disclosure relates to indole-type piperidine compounds, indoline-type piperidine compounds and related piperidine-type bicyclic compounds containing a five-membered nitrogen- containing ring (e.g., pyrrole or dihydropyrrole) fused to a heteroaryl ring, compositions comprising an effective amount of such compounds, and methods to treat or prevent a condition, such as pain, comprising ...

US4210590A - Reduction of indole compounds to indoline .

A method for reducing indole compounds to the corresponding indoline compounds substantially free of undesirable side reactions is described. The method involves contacting an indole compound with a borane complex reagent in the presence of trifluoroacetic acid. The method is rapidly and readily carried out and provides an excellent method for preparing certain indoline compounds from the ...

Indoline - an overview | ScienceDirect Topi

Indoline 236 was condensed with benzaldehyde 237 in the presence of catalytic amounts of benzoic acid; N-benzylindole 239 is formed from intermediate azomethine ylide 238 <11OL812>.The enantioselective N H functionalization of indole 242 was achieved by chiral phosphoric acid catalysis with α,β-unsaturated-γ-lactam 241 in 85% yield and 87% ee <11AG(I)5682>.

Indoline synthesis - organic-chemistry.o

A Brønsted acid catalyzed transfer hydrogenation of indole derivatives with Hantzsch dihydropyridine as the hydrogen source enables an efficient synthesis of various optically active indolines with high enantioselectivities. M. Rueping, C. Brinkmann, A. P. Antonchick, I. Atoresei, Org. Lett., 2010, 12, 4604-4607.

Reduction of indole compounds to indoline compoun

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US4210590A - Reduction of indole compounds to indoline .

A method for reducing indole compounds to the corresponding indoline compounds substantially free of undesirable side reactions is described. The method involves contacting an indole compound with a borane complex reagent in the presence of trifluoroacetic acid. The method is rapidly and readily carried out and provides an excellent method for preparing certain indoline compounds from the ...

WO2014102588A3 - Indole and indoline-type piperidine .

The disclosure relates to indole-type piperidine compounds, indoline-type piperidine compounds and related piperidine-type bicyclic compounds containing a five-membered nitrogen- containing ring (e.g., pyrrole or dihydropyrrole) fused to a heteroaryl ring, compositions comprising an effective amount of such compounds, and methods to treat or prevent a condition, such as pain, comprising ...

Selective hydrogenation of unprotected indole to indoline .

Mesoporous N-doped carbon supported palladium catalyst [email protected] 0.132 was able to efficiently catalyze unprotected indole to indoline under mild conditions. In the aqueous system, a selectivity of 100% and conversion of 96% was achieved under 313 K and atmospheric hydrogen gas.

Indoline Dehydrogenation | Gordon W. Gribble | Request P

Pratt and McGovern first described the dehydrogenation of indoline to indole in 59% yield using manganese dioxide (benzene, reflux, water removal); however, according to the authors, the yield ...

Reduction of indoles and related compoun

Reduction of indoles and related compounds. Brian Robinson. Chem. Rev., 1969, 69 (6), ... Indole-3-carboxylic Esters, Indole-3-sulfinic Acids, and 3-(Methylsulfonyl)indoles from Free ... Reduction of indoles and alkylation of aromatic amines with carboxylic acids.

Reduction of indole compounds to indoline compoun

A method for reducing indole compounds to the corresponding indoline compounds substantially free of undesirable side reactions is described. The method involves contacting an indole compound with a borane complex reagent in the presence of trifluoroacetic acid.

Indole - Wikiped

Indole is an aromatic heterocyclic organic compound with formula C8H7N. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered pyrrole ring. Indole is widely distributed in the natural environment and can be produced by a variety of bacteria. As an intercellular signal molecule, indole regulates various ...

WO2014102588A3 - Indole and indoline-type piperidine .

The disclosure relates to indole-type piperidine compounds, indoline-type piperidine compounds and related piperidine-type bicyclic compounds containing a five-membered nitrogen- containing ring (e.g., pyrrole or dihydropyrrole) fused to a heteroaryl ring, compositions comprising an effective amount of such compounds, and methods to treat or prevent a condition, such as pain, comprising ...

US4210590A - Reduction of indole compounds to indoline .

A method for reducing indole compounds to the corresponding indoline compounds substantially free of undesirable side reactions is described. The method involves contacting an indole compound with a borane complex reagent in the presence of trifluoroacetic acid. The method is rapidly and readily carried out and provides an excellent method for preparing certain indoline compounds from the ...