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Recombination Based Telomere Maintenance Is Dependent on

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Long telomeres are preferentially extended during .

telomeric DNA through recombination-dependent DNA replica-tion18, probably involving extrachromosomal circular DNA contain-ing telomeric repeat sequences19,20. The similarities between type II survivors and human ALT cells make yeast an attractive model in which to study recombination-based telomere maintenance.

CiteSeerX — Recombination-Based Telomere Maintenance Is .

CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Fission yeast cells survive loss of the telomerase catalytic subunit Trt1 (TERT) through recombination-based telomere maintenance or through chromosome circularization. Although trt1 survivors with linear chromo-somes can be obtained, they often spontaneously circularize their chromosomes.

Telomere Maintenance and Survival in Saccharomyces .

Telomere Maintenance and Survival in Saccharomyces cerevisiae ... also deleted, this survival is RAD52 dependent. Unexpectedly, we found that the S. cerevisiae strain S288C ... replenishing telomere DNA via a recombination-based mechanism (Lundblad and Blackburn 1993; Le et al.

break-induced replication and telomerase-independent .

break-induced replication and telomerase-independent telomere maintenance require Pol32_生物学_自然 ... BIR presumably involves recombination-dependent involving ...

Sumoylation and the Structural Maintenance of Chromosomes .

Potts and Yu proposed that the primary role of SMC5/6 SUMO ligase activity is to mediate the efficient recruitment/retention of telomeres to APBs to properly engage recombination-based pathways of telomere maintenance. Our study suggests that the SMC5/6 complex does not simply function to recruit telomeres to APBs because yeast have no known ...

Recombination-Mediated Telomere Maintenance in .

If this is the case, it will be interesting to figure out how the Shu complex differentiates between one-ended and two-ended DSBs. Finally, while the role of recombination in telomerase-independent telomere maintenance is clear, it is much less obvious why recombination proteins are needed to prevent accelerated senescence.

Recombination-Mediated Telomere Maintenance in .

Recombination-Mediated Telomere Maintenance in Saccharomyces cerevisiae Is Not Dependent ... A subset of these cells can overcome senescence and maintain their telomeres using recombination-based processes, becoming ... Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae ...

ALTernative Telomere Maintenance and Cancer - cell.c

Activation of a telomere maintenance mechanism (TMM) is permissive for replicative immortality and a hallmark of human cancer. While most cancers rely on reactivation of telomerase, a significant fraction utilizes the recombination-dependent alternative lengthening of telomeres (ALT) pathway. ALT is enriched in tumors of mesenchymal origin, including those arising from bone, soft tissue, and ...

MicroRNA-dependent Regulation of Telomere Maintenance .

Abstract: The activation of telomere maintenance mechanisms, which rely on telomerase reactivation or on a recombination-based process known as alternative lengthening of telomeres, guarantees a limitless proliferative potential to human tumor cells.

Loss of Rap1 supports recombination-based telomere .

Loss of Rap1 supports recombination-based telomere maintenance independent of RNA-DNA hybrids in fission yeast Authors: Hu, Yan and Bennett, Henrietta W and Liu, Na and Moravec, Martin and Williams, Jessica F and Azzalin, Claus M and King, Megan C

Telomere maintenance by telomerase and by recombination .

Immortal human cells maintain their telomeres by two independent mechanisms, a prevalent one dependent on de novo synthesis of telomeric DNA by telomerase, and a rarer one based on telomere recombination [alternative lengthening of telomeres (ALT)]. Studies with yeast have indicated that expression of telomerase inhibits telomere recombination.

CiteSeerX — Recombination-Based Telomere Maintenance Is .

CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Fission yeast cells survive loss of the telomerase catalytic subunit Trt1 (TERT) through recombination-based telomere maintenance or through chromosome circularization. Although trt1 survivors with linear chromo-somes can be obtained, they often spontaneously circularize their chromosomes.

Telomere Maintenance Mechanisms: Prognostic and .

In neoplasia, telomere maintenance mechanisms (TMMs) can be prognostic and may direct therapy in the future. Two types of TMM, telomerase and recombination-based alternative lengthening of telomeres (ALT), result in four prognostic tumor groups when they occur individually, in combination, or in mutual absence. Correct designation of the TMM therefore requires an assessment of telomerase ...

Telomere maintenance is dependent on activities required .

Telomeres are functionally distinct from ends generated by chromosome breakage, in that telomeres, unlike double-strand breaks, are insulated from recombination with other chromosomal termini .We report that the Ku heterodimer and the Rad50/Mre11/Xrs2 complex, both of which are required for repair of double-strand breaks , , , , have separate roles in normal telomere maintenance in yeast.

Recombination-Based Telomere Maintenance Is Dependent on Tel1-MRN and Rap1 and Inhibited by Telomerase, Taz1, and Ku in Fission Yea

Taz1 and catalytically inactive TERT inhibit recombination-based telomere maintenance. The recombination-based telomere maintenance in taz1Δ trt1Δ cells is highly efficient, presumably because changes in the telomeric chromatin structure in the absence of Taz1 allow better access for recombination enzymes to telomeres .

Recombination-based telomere maintenance is dependent on .

Recombination-based telomere maintenance is dependent on Tel1-MRN and Rap1 and inhibited by telomerase, Taz1, and Ku in fission yeast. Subramanian L., Moser B.A., Nakamura T.M. Fission yeast cells survive loss of the telomerase catalytic subunit Trt1 (TERT) through recombination-based telomere maintenance or through chromosome circularization.

RNA-DNA hybrids support recombination-based telomere .

To investigate the molecular changes needed for cells to maintain their telomeres by recombination, we monitored telomere appearance during serial culture of fission yeast ( Schizosaccharomyces pombe ) cells lacking the telomerase recruitment factor Ccq1. Rad52 is loaded onto critically short telomeres shortly after germination despite continued telomere erosion, suggesting that recruitment of ...

Long telomeres are preferentially extended during .

Most human somatic cells do not express telomerase. Consequently, with each cell division their telomeres progressively shorten until replicative senescence is induced. Around 15% of human cancers ...

SFPQ and NONO suppress RNA:DNA-hybrid-related telomere .

Our study introduces NONO and SFPQ as novel regulators of RNA:DNA-hybrid management that may open new inroads in defining strategies that aim to target recombination-based pathways of telomere ...

Recombination in telomere-length maintenance - ScienceDire

There is evidence that telomerase is the predominant mechanism for telomere maintenance in most eukaryotic cells 11.However, over the last ten years, experiments have shown that a recombination mechanism for telomere elongation might play an important role in telomere maintenance.

Roles of Heterochromatin and Telomere Proteins in .

Based on the results presented in the current and previous papers, we can begin to establish a hierarchical order of the numerous proteins involved in telomere maintenance both for the inhibition of telomere recombination (Fig. 8 A) and for the telomerase-dependent telomere extension (Fig. 8 B).