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AMBRA1 links autophagy to cell proliferation and

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AMBRA1 Antibody (26190002): Novus Biologica

Cianfanelli V, Fuoco C, Lorente M et al. AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation. Nat Cell Biol 2015 Jan [PMID: 25438055] (WB) WB: Strappazzon F, Nazio F, Corrado M et al. AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1.

Erratum: AMBRA1 links autophagy to cell proliferation and .

Erratum: AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation (Nature Cell Biology (2015) 17 (20-30)). Nature Cell Biology , 17 (5), 706.

AMBRA1 links autophagy to cell proliferation and .

TY - JOUR. T1 - AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation. AU - Cianfanelli, Valentina

Autophagy in cellular growth control - ScienceDire

Specifically, increased proliferation of mammary epithelial cells and splenic lymphocytes has been noted in beclin 1 heterozygous-deficient mice and increased neural cell proliferation has been noted in Ambra1-deficient embryonic mice , . The mechanism by which autophagy inhibits cell proliferation is not clear.

AMBRA1 links autophagy to cell proliferation and .

AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation. Authors: Valentina Cianfanelli Claudia Fuoco Mar Lorente Maria Salazar Fabio Quondamatteo Pier Federico Gherardini Daniela De Zio Francesca Nazio Manuela Antonioli Melania D'Orazio Tatjana Skobo Matteo Bordi Mikkel Rohde Luisa ...

miR-9-5p靶向Ambra1促进舌癌细胞增

and silencing miR-9-5p promoted tongue cancer cell proliferation via directly targeting Ambra1. Key words: miR-9-5p ... miR-9-5p activating molecule in beclin1 ...

AMBRA1 and BECLIN 1 interplay in the crosstalk between .

Autophagy-promoting proteins and stimuli are often associated with inhibition of cell proliferation; in this context, we recently described a key role for the pro-autophagic protein AMBRA1. Indeed, AMBRA1, through its direct interaction with the protein phosphatase PP2A, tightly regulates the ...

Transcription factor E2-2 inhibits the proliferation of .

Interestingly, CQ reversed the increase in cell proliferation and autophagy in the E2-2 knockdown group. Furthermore, we detected the expression of autophagy‑related protein ATG7 in EPCs which had been transfected with small interfering (siRNA)‑E2-2 and siRNA‑autophagy related 7 (ATG7) or were untransfected.

AMBRA1 links autophagy to cell proliferation and .

Nat Cell Biol. 2015 May;17(5):706. doi: 10.1038/ncb3171. AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation. Cianfanelli V, Fuoco C, Lorente M, Salazar M, Quondamatteo F, Gherardini PF, De Zio D, Nazio F, Antonioli M, D'Orazio M, Skobo T, Bordi M, Rohde M, Dalla Valle L, Helmer ...

Increased Amino Acid Uptake Supports Autophagy ... - cell.c

Cell proliferation was then tested with the CCK8 assay (D). Propidium iodide (PI)-stained (dead) cells were counted by flow cytometry, and the percentage cell death was calculated (E). ... AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation. Nat. Cell Biol. 2015; 17: 20-30.

标题:AMBRA1 links autophagy to cell proliferation and .

摘要:Inhibition of a main regulator of cell metabolism, the protein kinase mTOR, induces autophagy and inhibits cell proliferation. However, the molecular pathways involved in ...

miR-9-5p Promotes the Proliferation of Tongue Cancer Cells .

miR-9-5p Promotes the Proliferation of Tongue Cancer Cells by Targeted Suppression of Ambra1: CHEN Wei-Quan*, YANG Hong, TAN Guang-Mou, HUANG Hai-Yan, LIAO Wei-Guo, HUANG Wen-Xi, WEN Qing-Quan, QI Qi-Guang, WU Di (Department of Head and Neck, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou 510095, China)

AMBRA1 Controls Regulatory T-Cell Differentiation and .

Regulatory T cells (Treg) maintain immunological tolerance and help control autoimmune disease susceptibility. Becher et al. show pro-autophagy factor AMBRA1 regulates human and mouse Treg differentiation and maintenance. AMBRA1 is upregulated in stimulated T cells to stabilize FOXO3 and has a protective effect in a mouse model of multiple sclerosis.

AMBRA1 links autophagy to cell proliferation and .

Nature cell biology 2014-12-2 AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation. [Valentina Cianfanelli, Claudia Fuoco, Mar Lorente, Maria Salazar, Fabio Quondamatteo, Pier Federico Gherardini, Daniela De Zio, Francesca Nazio, Manuela Antonioli, Melania D'Orazio, Tatjana Skobo, Matteo Bordi, Mikkel Rohde, Luisa Dalla Valle ...

AMBRA1 links autophagy to cell proliferation and .

Inhibition of a main regulator of cell metabolism, the protein kinase mTOR, induces autophagy and inhibits cell proliferation. However, the molecular pathways involved in the cross-talk between these two mTOR-dependent cell processes are largely unknown. Here we show that the scaffold protein AMBRA1 ...

AMBRA1 links autophagy to cell proliferation and .

Here we show that the scaffold protein AMBRA1, a member of the autophagy signalling network and a downstream target of mTOR, regulates cell proliferation by facilitating the dephosphorylation and degradation of the proto-oncogene c-Myc.

Transcription factor E2-2 inhibits the proliferation of .

E2-2 inhibits the proliferation of endothelial progenitor cells (EPCs) via suppressing autophagy. ... Quondamatteo F, Gherardini PF, De Zio D, Nazio F, Antonioli M, D'Orazio M, et al: AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation. Nat Cell Biol. 17:20–30. 2015. View Article ...

Neurodevelopmental Disorders: Functional Role of Ambra1 in .

Cianfanelli V, Fuoco C, Lorente M, Salazar M, Quondamatteo F, Gherardini PF, de Zio D, Nazio F et al (2015) AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-MYC dephosphorylation and degradation. Nat Cell Biol 17:20–30.

AMBRA1-Mediated Regulation of C-MYC and Its Relevance to .

AMBRA1-mediated regulation of C-MYC. AMBRA1, in a complex with the protein phosphatase PP2A, mediates C-MYC dephosphorylation and its proteasomal degradation, hence restraining cell proliferation. Importantly, AMBRA1/PP2A activity toward C-MYC is inhibited by mTORC1, the master regulator of cell proliferation and autophagy.

AMBRA1 links autophagy to cell proliferation and .

mTOR signalling both inhibits autophagy and promotes cell proliferation. Cecconi and colleagues report that AMBRA1 links these two processes by facilitating dephosphorylation and degradation of ...

Neurodevelopmental Disorders: Functional Role of Ambra1 in .

Cianfanelli V, Fuoco C, Lorente M, Salazar M, Quondamatteo F, Gherardini PF, de Zio D, Nazio F et al (2015) AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-MYC dephosphorylation and degradation. Nat Cell Biol 17:20–30.