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Differential repair of etheno DNA adducts by bacterial and

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Switching Demethylation Activities between AlkB Family RNA .

Falnes, Carmelo J. Rizzo, F. Peter Guengerich and Barbara Tudek, Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins, DNA Repair, 30, (1), (2015). Crossref

Ultrasensitive Quantitative PCR to Detect RNA Viruses .

etheno,dna,adducts,human,tissues,white,blood,cells,urine,ultrasensitive,32p-postlabeling,32,p,postlabeling ... Quantitative DNA Damage and Repair 25. ...

Carmelo J. Rizzo | Faculty | Department of Chemistry .

If these modifications are not repaired, they can compromise the fidelity of DNA replication leading to mutations and possibly cancer. To properly study the biological processing of pre-mutagenic DNA lesions, oligonucleotides containing structurally defined carcinogen adducts are required.

DNA repair and protection mechanisms in - core.ac.

DNA repair and protection mechanisms in Escherichia coli and Mycobacterium tuberculosis ... Differential proteomic approach to the study of E.coli upon exposure to methylating agent.41 ... bifunctional alkylating agent produces etheno DNA adducts including 1,N6-Chapter 1: Introduction ...

Publications | Rizzo Laboratory | Vanderbilt Universi

Publications. ORCID: 0000-0001-9005-611X SCOPUS ID: 7102642628 2019 (129) Chen, H., Yao, L., Rizzo, C. J., Turesky, R. J. Quantitation of Apurinic/Apyrimidinic Sites ...

Rizzo Lab: Publications - Vanderbilt Universi

Publications. 2016 (125) Bose, A., Millsap, A..D., DeLeon A., Rizzo, C.J., Basu, A .K (2016) . (2016) Translesion Synthesis of the N2-2'-Deoxyguanosine Adduct of the ...

DNA Repair | Vol 30, Pages 1-104 (June 2015 .

Read the latest articles of DNA Repair at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature ... select article Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins. Research article Full text access Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins ...

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Chemistry Tree - Carmelo Riz

Zdżalik D, Domańska A, Prorok P, et al. (2015) Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins. Dna Repair . 30: 1-10 See more...

Differential repair of etheno-DNA adducts by bacterial and .

Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins By Daria Zdżalik, Anna Domańska, Paulina Prorok, Konrad Kosicki, Erwin van den Born, Päl Ø Falnes, Carmelo J Rizzo, Peter F Guengerich and Barbara Tudek

Molecular Mechanisms of the Whole DNA Repair System: A .

DNA is subjected to many endogenous and exogenous damages. All organisms have developed a complex network of DNA repair mechanisms. A variety of different DNA repair pathways have been reported: direct reversal, base excision repair, nucleotide excision repair, mismatch repair, and recombination repair pathways. Recent studies of the fundamental mechanisms for DNA repair processes have ...

Escherichia coli Responses to a Single DNA Adduct .

The results are used to analyze mechanisms of responses to a DNA adduct. In this study, we conducted experiments using a single 1,N 6-ethenodeoxyadenosine (ɛdA). ɛdA is one of four etheno DNA adducts, including 3,N 4-etheno dC,N 2,3-etheno dG, and 1,N 2-etheno dG, that are produced by both endogenous and exogenous agents (23, 36).

Direct Repair of the Exocyclic DNA Adduct 1,N6 .

Direct Repair of the Exocyclic DNA Adduct 1,N6-Ethenoadenine by the DNA Repair AlkB Proteins. ... Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins. Daria Zdżalik, Anna Domańska, ... Human DNA glycosylase enzyme TDG repairs thymine mispaired with exocyclic etheno-DNA adducts. Masanori Goto, Kazuya Shinmura ...

Exocyclic Carbons Adjacent to the N6 of Adenine are .

The DNA and RNA repair protein AlkB removes alkyl groups from nucleic acids by a unique iron- and α-ketoglutarate-dependent oxidation strategy. When alkylated adenines are used as AlkB targets, earlier work suggests that the initial target of oxidation can be the alkyl carbon adjacent to N1. Such may be the case with ethano-adenine (EA), a DNA adduct formed by an important anticancer drug ...

Medscape | DNA Repair (Amst) - Publication Informati

Table of Contents 2015 - 30 Cell cycle regulation of human DNA repair and chromatin remodeling genes. June 01, 2015 [ MEDLINE Abstract] Topoisomerase I deficiency causes RNA polymerase II ...

Differential repair of etheno-DNA adducts by bacterial and .

In vitro repair assay of DNA etheno adducts. Repair reactions of the ɛ-adducts in DNA with bacterial AlkB proteins were performed by incubating 100 pmol of the appropriate bacterial AlkB protein with 1 pmol of ss or ds 32 P-labeled DNA oligodeoxynucleotide at 37 °C for 30 min in a 50 μL reaction mixture containing 50 mM Tris–HCl (pH 7.0 ...

Rhizobium etli - medd

Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins. Zdżalik D1, Domańska A2, Prorok P3, Kosicki K1, van den Born E4, Falnes PØ4, Rizzo ...

Mechanisms of the dna repair in bacterial and yeast cells .

Repair of exocyclic, unsubstituted etheno-DNA adducts is realized mainly by base excision repair pathway (1). 1,N 2-propanoguanosine with a hexyl side chain derived from hydroxynonenal interaction with DNA was shown to be eliminated by nucleotide excision repair in mammalian cells (2, 3).

The AlkB Family of Fe(II)/α-Ketoglutarate-dependent .

Abstract. The AlkB family of Fe(II)- and α-ketoglutarate-dependent dioxygenases is a class of ubiquitous direct reversal DNA repair enzymes that remove alkyl adducts from nucleobases by oxidative dealkylation.

Molecular Mechanisms of the Whole DNA Repair System: A .

DNA is subjected to many endogenous and exogenous damages. All organisms have developed a complex network of DNA repair mechanisms. A variety of different DNA repair pathways have been reported: direct reversal, base excision repair, nucleotide excision repair, mismatch repair, and recombination repair pathways. Recent studies of the fundamental mechanisms for DNA repair processes have ...