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Relapsed classic E Cadherin CDH1 mutated invasive

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Nonamplification ERBB2 genomic alterations in 5605 cases .

In addition, the comutation frequency of 37% observed further validates an association between ERBB2mut and clinically recurrent CDH1 (E‐cadherin)‐mutated (CDH1mut) lobular breast cancer, as previously described. 11

Effects of UPF1 expression on EMT process by targeting E .

In summary, E‑cadherin expression levels were regulated by the manifold, and UPF1, a potential tumor suppressor, may promote the EMT process in Huh‑7 HCC cells. The findings of the present study suggested that UPF1 expression levels affected the EMT process by targeting E‑cadherin, N‑cadherin, Vimentin and Twist.

Insertional mutagenesis identifies drivers of a novel .

Ross, J.S. et al. Relapsed classic E-cadherin (CDH1)-mutated invasive lobular breast cancer shows a high frequency of HER2 (ERBB2) gene mutations. Clin. Cancer Res. 19 , 2668–2676 (2013).

Loss of function of NF1 is a mechanism of acquired .

Invasive lobular carcinoma (ILC) as a disease entity distinct from invasive ductal carcinoma (IDC) has merited focused studies of the genom ... Relapsed classic E-cadherin (CDH1)-mutated invasive lobular breast cancer shows a high frequency of HER2 (ERBB2) gene mutations.

Oncotarget | ERBB2 mutation is associated with a worse .

ABSTRACT. E-cadherin (CDH1) is a glycoprotein that mediates adhesion between epithelial cells and also suppresses cancer invasion.Mutation or deletion of the CDH1 gene has been reported in 30–60% cases of invasive lobular carcinoma (ILC). However, little is known about genomic differences between ILC with and without a CDH1 alteration. Therefore, we analyzed whole genome sequencing data of ...

Relapsed Classic E-Cadherin (CDH1)–Mutated Invasive Lobular Breast Cancer Shows a High Frequency of HER2 (ERBB2) Gene Mutatio

Relapsed Classic E-Cadherin (CDH1)–Mutated Invasive Lobular Breast Cancer Shows a High Frequency of HER2 (ERBB2) Gene Mutations Jeffrey S. Ross , Kai Wang , Christine E. Sheehan , Ann B. Boguniewicz , Geoff Otto , Sean R. Downing , James Sun , Jie He , John A. Curran , Siraj Ali , Roman Yelensky , Doron Lipson , Gary Palmer , Vincent A ...

LobSig is a multigene predictor of outcome in invasive .

Invasive lobular carcinoma (ILC) is the most common special type of breast cancer, and is characterized by functional loss of E-cadherin, resulting in cellular adhesion defects.

Relapsed classic E-cadherin (CDH1) mutated invasive .

Relapsed classic E-cadherin (CDH1) mutated invasive lobular breast cancer demonstrates a high frequency of HER2 (ERBB2) gene mutations NBC 180 - A partir d'échantillons tumoraux prélevés sur 22 patientes atteintes d'un carcinome lobulaire invasif

clinical case of invasive lobular breast carcinoma with .

ILC represents 10% of breast cancers and differs from ductal carcinoma by the loss of E-cadherin function and lower ERBB2-amplification rate . E-cadherin loss can be due to CDH1 mutation, which is observed in up to 83% of ILCs . Interestingly, Ross et al. described an 18% of ERBB2 mutations (4/22) in CDH1-mutated metastatic ILC .

Relapsed classic E-cadherin (CDH1)-mutated invasive .

Relapsed classic E-cadherin (CDH1)-mutated invasive lobular breast cancer shows a high frequency of HER2 (ERBB2) gene mutations. ... CONCLUSIONS: Comprehensive genomic profiling of relapsed CDH1-mutated ILC revealed actionable genomic alterations in 86% of cases, featured a high incidence of ERBB2 alterations, and can reveal actionable ...

Treatment of Patients With Lobular Breast Cancer Harboring .

CDH1 encodes the transmembrane protein E-cadherin, which plays an important role in epithelial cell-cell adhesion. Mutations in CDH1 have been reported in 62% to 100% of cases of invasive lobular carcinoma, and many investigators consider a mutation in CDH1 to represent a genomic alteration characteristic of lobular carcinoma. 5

Comprehensive molecular portraits of invasive lobular .

Ross JS, Wang K, Sheehan CE, Boguniewicz AB, Otto G, Downing SR, Sun J, He J, Curran JA, Ali S, et al. Relapsed classic E-cadherin (CDH1)-mutated invasive lobular breast cancer shows a high frequency of HER2 (ERBB2) gene mutations. Clinical cancer research : an official journal of the American Association for Cancer Research. 2013; 19:2668–2676.

Medscape | Clin Cancer Res - Publication Informati

Relapsed classic E-cadherin (CDH1)-mutated invasive lobular breast cancer shows a high frequency of HER2 (ERBB2) gene mutations. May 15, 2013 [ MEDLINE Abstract] Oncolytic virotherapy needs trials, not access programs. May 15, 2013 [ MEDLINE Abstract]

Relapsed classic E-cadherin (CDH1)-mutated invasive .

Relapsed classic E-cadherin (CDH1)-mutated invasive lobular breast cancer shows a high frequency of HER2 (ERBB2) gene mutations. Authors: Jeffrey S Ross Kai Wang Christine E Sheehan Ann B Boguniewicz Geoff Otto Sean R Downing James Sun Jie He John A Curran Siraj Ali Roman Yelensky Doron Lipson Gary Palmer Vincent A Miller Philip J Stephens

ILC Research Reference List - The Lobular Breast Cancer .

The Lobular Breast Cancer Alliance has compiled a list of ILC research and studies related to lobular breast cancer. The list includes studies from 2000 to the present.

Lobular breast cancer: molecular basis, mouse and cellular .

Abstract. Infiltrating lobular breast cancer (ILC) is the most common special breast cancer subtype. With mutational or epigenetic inactivation of the cell adhesion molecule E-cadherin (CDH1) being confined almost exclusively to ILC, this tumor entity stands out from all other types of breast cancers.The molecular basis of ILC is linked to loss of E-cadherin, as evidenced by human CDH1 ...

Relapsed classic E-Cadherin (CDH1)-mutated invasive .

Relapsed classic E-Cadherin (CDH1)-mutated invasive lobular breast cancer shows a high frequency of HER2 (ERBB2) gene mutations Article (PDF Available) in Clinical Cancer Research 19(10) · April ...

A Neu View of Invasive Lobular Breast Cancer - Europe PMC .

A Neu View of Invasive Lobular Breast Cancer. Ron Bose 1, 2 ... and it has a significantly lower rate of HER2 gene amplification than invasive ductal breast cancer . E-cadherin ... Wang K, Sheehan CE, Boguniewicz A, Otto G, Downing SR, et al. Relapsed classic E-cadherin (CDH1) mutated invasive lobular breast cancer demonstrates a high frequency ...

Genomic Characterization of Primary Invasive Lobular .

Invasive lobular breast cancer (ILBC) is the most frequent special histologic type of breast cancer (5% to 15%) after invasive ductal breast cancer (IDBC). 1 This neoplasia is typically characterized by small, discohesive epithelial cells, which mostly express the estrogen receptor (ER, encoded by the ESR1 gene), lack HER2 (ERBB2) amplification, and lost the cell adhesion molecule E-cadherin ...